Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells
DOI:
https://doi.org/10.5454/mi.13.2.5Keywords:
Callyspongia sp., isocopalane diterpene, human pancreatic cancer cellsAbstract
The bioactive compound from the Indonesian Marine SpongeCallyspongia sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]+ 412.576 m/z indicate that the compound has molecular formula C24H44O5 determined by LCMS-ESI. This compound has bioactivity IC50 = 0.1 μg / mL against human pancreatic cancer cell.
Downloads
Published
2020-01-16
How to Cite
KURNIANDA, V., FARADILLA, S., KARINA, S., AGUSTINA, S., ULFAH, M., OCTAVINA, C., … MUSMAN, M. (2020). Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells. Microbiology Indonesia, 13(2), 5. https://doi.org/10.5454/mi.13.2.5
Issue
Section
Articles
License
Copyright (c) 2020 Microbiology Indonesia
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
